上海起发为broadpharm特约经销商,BroadPharm®成立于2009年,是加利福尼亚州圣地亚哥的一家的以客户为中心的生物技术公司。为制药和生物技术行业的客户提供知识产权保护的定制合成。
Broadpharm Alkyne PEG 系列产品
Sharpless及其同事在2001年定义了click化学来描述在温和的含水条件下快速和有选择性地相互作用(“click”)的成对官能团。click化学概念由于其温和的条件以及高选择性已经扩展到生物标记,化学生物学领域和药物研发。
总体上有三种click化学类型:
1 。铜(I)催化叠氮 - 炔click化学反应(CuAAC)
经典click化学使用铜作为催化剂,其需要适当的螯合配体,如TBTA和THPTA。TBTA涵盖了click化学的一些实际应用,除了含水偶联反应外,THPTA通过允许整个反应在水中运行进一步简化click化学,从而为click反应提供生物兼容性。
2.应变促进的叠氮 - 炔烃click化学反应(SPAAC)
由于需要细胞毒性铜催化剂,CuAAC反应在应用中受到限制。一种无铜无毒的叠氮化物标记方法是应变促进叠氮 - 炔click化学(SPAAC)反应。通过使用应变环辛炔而不需要外源催化剂,SPAAC反应具有显着降低的活化能。
3.四嗪 - 烯烃连接
Tetrazine - 烯烃连接非常适合体内细胞标记以及低浓度应用。四嗪官能化的分子可以与末端或应变的烯烃分子反应以通过二氢吡嗪部分形成稳定的缀合物,其被认为是无毒的生物分子标记方法。
示例协议:
本节包含click反应的一些常规协议。
注意:这些协议可能被引用作为进一步优化您自己的click化学程序的起点。
1. 在磷酸钠缓冲液中制备叠氮化物连接的抗体。
2. 通过SPAACclick化学,将叠氮化物修饰的抗体(400μg,在1mL TBS缓冲液中)与含有DBCO / DIBO / BCN部分的分子(200μL的2mM DMSO溶液)一起在室温下优化时间。
3. 终产品可根据需要通过尺寸排阻色谱法或其他方案进行纯化。
参考:Zeglis等。(2013),Bioconjugate Chemistry 24(6):1057
炔烃-PEG是一类具有三键的PEG接头。它广泛用于叠氮反应Click Chemical。PEG间隔臂增加这些接头的亲水性。
Broadpharm Alkyne PEG 系列产品 :
atalog No. | Name | M.W. | Purity |
BP-21981 | Propargyl-PEG1-acid | 128.1 | 98% |
BP-23165 | Propargyl-PEG2-acid | 172.2 | 98% |
BP-20678 | Propargyl-PEG3-acid | 216.2 | 98% |
BP-21094 | Propargyl-PEG4-acid | 260.3 | 98% |
BP-20649 | Propargyl-PEG5-acid | 304.3 | 98% |
BP-22764 | Propargyl-PEG6-acid | 348.4 | 98% |
BP-23423 | Propargyl-PEG7-acid | 392.5 | 98% |
BP-22811 | Propargyl-PEG8-acid | 436.5 | 98% |
BP-22822 | Propargyl-PEG10-acid | 524.6 | 98% |
BP-22597 | Propargyl-PEG13-acid | 656.8 | 98% |
BP-22855 | Propargyl-PEG14-acid | 700.8 | 98% |
BP-22737 | Propargyl-PEG4-CH2CO2H | 246.3 | 98% |
BP-23125 | Propargyl-PEG5-CH2CO2H | 290.3 | 98% |
BP-23117 | Propargyl-PEG4-(CH2)3-acid | 274.3 | 98% |
BP-23819 | Propargyl-PEG1-NHS ester | 225.2 | 95% |
BP-21613 | Propargyl-PEG3-NHS ester | 313.3 | 98% |
BP-21612 | Propargyl-PEG4-NHS ester | 357.4 | 98% |
BP-20907 | Propargyl-PEG5-NHS ester | 401.4 | 98% |
BP-23422 | Propargyl-PEG6-NHS ester | 445.5 | 98% |
BP-23458 | Propargyl-PEG7-NHS ester | 489.5 | 98% |
BP-23778 | Propargyl-PEG8-NHS ester | 533.6 | 95% |
BP-23811 | Propargyl-PEG4-CH2CO2-NHS | 343.3 | 95% |
BP-23812 | Propargyl-PEG5-CH2CO2-NHS | 387.4 | 95% |
BP-21980 | Propargyl-PEG1-t-butyl ester | 184.2 | 98% |
BP-22631 | Propargyl-PEG2-t-butyl ester | 228.3 | 98% |
BP-20677 | Propargyl-PEG3-t-butyl ester | 272.3 | 98% |
BP-21093 | Propargyl-PEG4-t-butyl ester | 316.4 | 98% |
BP-20651 | Propargyl-PEG5-t-butyl ester | 360.5 | 98% |
BP-22765 | Propargyl-PEG6-t-butyl ester | 404.5 | 98% |
BP-21070 | Propargyl-PEG7-t-butyl ester | 448.6 | 98% |
BP-22810 | Propargyl-PEG8-t-butyl ester | 492.6 | 98% |
BP-22819 | Propargyl-PEG10-t-butyl ester | 580.7 | 98% |
BP-22858 | Propargyl-PEG14-t-butyl ester | 756.9 | 98% |
BP-22300 | Propargyl-PEG4-CH2CO2tBu | 302.4 | 98% |
BP-23857 | Propargyl-PEG5-CH2CO2tBu | 346.4 | 96% |
BP-23604 | Alkyne-ethyl-PEG1-t-Butyl ester | 198.3 | 98% |
BP-21657 | Propargyl-PEG2-alcohol | 100.1 | 98% |
BP-20675 | Propargyl-PEG3-alcohol | 144.2 | 98% |
BP-21724 | Propargyl-PEG4-alcohol | 188.2 | 98% |
BP-20648 | Propargyl-PEG5-alcohol | 232.3 | 98% |
BP-22010 | Propargyl-PEG6-alcohol | 276.3 | 98% |
BP-20719 | Propargyl-PEG7-alcohol | 320.4 | 98% |
BP-22797 | Propargyl-PEG8-alcohol | 364.4 | 98% |
BP-22056 | Propargyl-PEG9-alcohol | 408.5 | 98% |
BP-22812 | Propargyl-PEG10-alcohol | 452.5 | 98% |
BP-22517 | Propargyl-PEG13-alcohol | 584.7 | 98% |
BP-22829 | Propargyl-PEG14-alcohol | 628.8 | 98% |
BP-22856 | Propargyl-PEG18-alcohol | 805.0 | 98% |
BP-22770 | Propargyl-PEG1-amine | 99.1 | 98% |
BP-22519 | Propargyl-PEG2-amine | 143.2 | 98% |
BP-21683 | Propargyl-PEG3-amine | 187.2 | 98% |
BP-22520 | Propargyl-PEG4-amine | 231.3 | 98% |
BP-22103 | Propargyl-PEG5-amine | 275.3 | 98% |
BP-22876 | Propargyl-PEG6-amine | 319.4 | 98% |
BP-22521 | Propargyl-PEG8-amine | 407.5 | 98% |
BP-23419 | Propargyl-PEG9-amine | 451.6 | 95% |
BP-23637 | Propargyl-PEG10-amine | 495.6 | 98% |
BP-23543 | Propargyl-PEG12-amine | 583.7 | 98% |
BP-23544 | Propargyl-PEG24-amine | 1112.4 | 98% |
BP-21677 | Propargyl-PEG3-azide | 213.2 | 98% |
BP-23357 | Propargyl-PEG5-azide | 301.3 | 98% |
BP-23853 | Propargyl-PEG6-azide | 345.4 | 98% |
BP-22874 | Propargyl-PEG9-azide | 477.6 | 98% |
BP-22738 | Propargyl-PEG3-bromide | 251.1 | 98% |
BP-22782 | Propargyl-PEG4-bromide | 295.2 | 98% |
BP-22875 | Propargyl-PEG8-bromide | 471.4 | 98% |
BP-23120 | Propargyl-PEG9-bromide | 515.4 | 98% |
BP-22857 | Propargyl-PEG13-bromide | 691.7 | 98% |
BP-22683 | Propargyl-PEG4-Maleimide | 382.4 | 90% |
BP-21675 | Bis-propargyl-PEG2 | 138.2 | 98% |
BP-20676 | Bis-propargyl-PEG3 | 182.2 | 98% |
BP-21071 | Bis-propargyl-PEG4 | 226.3 | 98% |
BP-20660 | Bis-propargyl-PEG5 | 270.3 | 98% |
BP-21965 | Bis-propargyl-PEG6 | 314.4 | 98% |
BP-20718 | Bis-propargyl-PEG7 | 358.4 | 98% |
BP-23883 | Bis-propargyl-PEG8 | 402.5 | 97% |
BP-22057 | Bis-propargyl-PEG9 | 446.5 | 98% |
BP-22828 | Bis-propargyl-PEG10 | 490.6 | 98% |
BP-22514 | Bis-propargyl-PEG13 | 622.8 | 98% |
BP-22842 | Bis-propargyl-PEG18 | 843.0 | 98% |
BP-22930 | N-Me-N-bis(PEG2-propargyl) | 283.4 | 98% |
BP-22929 | Propargyl-PEG2-methylamine | 157.2 | 98% |
BP-22831 | Propargyl-PEG4-methylamine | 245.3 | 98% |
BP-22921 | Propargyl-PEG3-Ms | 222.3 | 98% |
BP-24026 | Propargyl-PEG6-Ms | 354.4 | 97% |
BP-22873 | Propargyl-PEG4-sulfonic acid | 296.3 | 98% |
BP-23139 | Propargyl-PEG4-thiol | 248.3 | 90% |
BP-22989 | Propargyl-PEG4-5-nitrophenyl carbonate | 397.4 | 95% |
BP-23163 | t-Boc-aminooxy-PEG1-propargyl | 215.3 | 98% |
BP-23129 | t-Boc-aminooxy-PEG2-propargyl | 259.3 | 98% |
BP-22775 | t-Boc-aminooxy-PEG3-propargyl | 303.4 | 98% |
BP-23142 | t-Boc-aminooxy-PEG4-propargyl | 347.4 | 98% |
BP-23475 | t-Boc-aminooxy-PEG5-propargyl | 391.5 | 98% |
BP-23474 | t-Boc-aminooxy-PEG6-propargyl | 435.5 | 98% |
BP-23164 | Aminooxy-PEG1-propargyl HCl salt | 115.1 | 98% |
BP-22774 | Aminooxy-PEG3-propargyl | 203.2 | 95% |
BP-22987 | Aminooxy-PEG4-propargyl | 247.3 | 98% |
BP-22087 | Propargyl-PEG4-methane | 202.3 | 98% |
BP-22376 | Propargyl-PEG5-methane | 246.3 | 98% |
BP-22088 | Propargyl-PEG17-methane | 774.9 | 98% |
BP-23109 | Propargyl-PEG4-(CH2)3-methyl ester | 288.3 | 98% |
BP-23869 | APN-C3-PEG4-alkyne | 469.5 | 97% |
BP-21658 | Propargyl-PEG2-acrylate | 154.2 | 98% |
BP-21540 | endo-BCN-PEG2-acid | 353.4 | 95% |
BP-22523 | endo-BCN-PEG3-acid | 397.5 | 95% |
BP-21538 | endo-BCN-PEG4-acid | 441.5 | 95% |
BP-23768 | endo-BCN-PEG8-acid | 617.7 | 95% |
BP-23767 | endo-BCN-PEG12-acid | 794.0 | 95% |
BP-24010 | endo-BCN-PEG3-NHS ester | 494.5 | 95% |
BP-22851 | endo-BCN-PEG4-NHS ester | 538.6 | 95% |
BP-23765 | endo-BCN-PEG8-NHS ester | 714.8 | 95% |
BP-23766 | endo-BCN-PEG12-NHS ester | 891.0 | 95% |
BP-21541 | endo-BCN-PEG2-PFP ester | 519.5 | 95% |
BP-21539 | endo-BCN-PEG4-PFP ester | 607.6 | 95% |
BP-21518 | endo-BCN-PEG4-t-butyl ester | 497.6 | 95% |
BP-21519 | endo-BCN-PEG6-t-butyl ester | 585.7 | 95% |
BP-22134 | endo-BCN-PEG2-alcohol | 325.4 | 95% |
BP-21520 | endo-BCN-PEG3-Boc-amine | 468.6 | 95% |
BP-23401 | bis-PEG2-endo-BCN | 500.6 | 95% |
BP-23748 | Boc-Gly-PEG3-endo-BCN | 553.7 | 95% |
BP-22014 | exo-BCN-PEG2-Boc-amine | 424.5 | 95% |
BP-23548 | Hydroxy-Amino-bis(PEG2-propargyl) | 313.4 | 98% |
BP-23585 | N-(Propargyl-PEG2)-N-bis(PEG1-alcohol) | 319.4 | 97% |
BP-23506 | N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt | 727.9 | 98% |
BP-23550 | N-(Acid-PEG2)-N-bis(PEG2-propargyl) | 429.5 | 98% |
BP-23580 | N-(Amino-PEG1)-N-bis(PEG2-propargyl) HCl salt | 356.5 | 98% |
BP-23613 | NH-bis(PEG2-propargyl) | 269.3 | 97% |
BP-23610 | N-Boc-N-bis(PEG2-propargyl) | 369.5 | 97% |
BP-23563 | N-(Boc-PEG1)-N-bis(PEG2-propargyl) | 456.6 | 97% |
BP-23651 | N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) | 504.6 | 98% |
BP-23638 | N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) | 604.7 | 97% |
BP-23549 | N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl) | 485.6 | 98% |
BP-23468 | N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester | 503.6 | 98% |
BP-23587 | N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) | 519.6 | 97% |
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